Modulation of the inflammatory response in severe sepsis
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Modulation of the inflammatory response in severe sepsis

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Published by Karger in Basel, New York .
Written in English


  • Sepsis -- Congresses.,
  • Inflammation -- Congresses.,
  • Sepsis -- Immunological aspects -- Congresses.,
  • Septic shock -- Congresses.,
  • Sepsis -- immunology -- congresses.,
  • Inflammation -- immunology -- congresses.,
  • Sepsis -- physiopathology -- congresses.,
  • Inflammation -- physiopathology -- congresses.

Book details:

Edition Notes

Statementvolume editors, J.M. Tellado, R.A. Forse, J.S. Solomkin.
SeriesProgress in surgery ;, vol. 20
ContributionsTellado, J. M., Forse, R. Armour, Solomkin, J. S.
LC ClassificationsRC182.S4 M63 1995
The Physical Object
Paginationvii, 188 p. :
Number of Pages188
ID Numbers
Open LibraryOL1272224M
ISBN 103805560419
LC Control Number95003517

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Inflammation and Sepsis. severe sepsis and septic shock remains high. The poor outcome is considered to be a consequence of an overactive systemic . This book deals with the central role of cytokines in the generalized inflammatory response of the host as the consequence of severe infection/endotoxin action. International specialists cover several aspects in 20 chapters starting with the agents responsible (endotoxin, superantigens) and recognition during cytokine induction. Further chapters deal with the signal transduction cascade, its. The severe sepsis patients retained twice the volume of fluid of those with major trauma, and the return to normal hydration in the sepsis group was correspondingly prolonged, especially for those. The clinical process of severe sepsis is characterized by extreme inflammation interlinked with potent stimulation of the coagulation cascade often followed by a state of relative immune paralysis. In this paper, we will review many of the potential therapies directed at various steps along the inflammatory cascade from modulation of inflammatory mediators eliciting the immune response Cited by:

Sepsis is a life-threatening condition that arises when the body's response to infection causes injury to its tissues and organs. Common signs and symptoms include fever, increased heart rate, increased breathing rate, and confusion. There may also be symptoms related to a specific infection, such as a cough with pneumonia, or painful urination with a kidney ciation: /ˈsɛpsɪs/. Sepsis, complement and the dysregulated inflammatory response Peter A. Ward a, *, Hongwei Gao b aThe University of Michigan Medical School, Department of Pathology, Ann Arbor, MI, USA bCenter for Experimental Therapeutics and Reperfusion Injury, Brigham and Women’s Hospital, Department of Anesthesiology, Perioperative & Pain Medicine, Harvard Medical School, Boston, MA, USACited by:   Numerous therapies aimed at reducing the pro-inflammatory burden of acute sepsis have been studied in clinical trials, with most producing disappointing results. The inflammatory response to sepsis has since been shown to be highly dynamic, with a period of compensatory down-regulation of the pro-inflammatory response dominating in the subacute Cited by: 6. Severe sepsis is a major cause of admission to the intensive care unit (ICU) and death. 1,2 The criteria according to the systemic inflammatory response syndrome (SIRS) were described 23 years ago Cited by:

Impaired healing in sepsis. The global physiologic changes characteristic of sepsis or septic inflammatory response are governed by a heightened production and release of inflammatory cytokines with their concomitant dysregulation. This extended production of acute phase proteins may be likened to a light switch stuck in the on : David T Efron, Adrian Barbul. The pathophysiology of sepsis and its accompanying systemic inflammatory response syndrome (SIRS) and the events that lead to multiorgan failure and death are poorly understood. It is known that, in septic humans and rodents, the development of SIRS is associated with a loss of the redox balance, but SIRS can also develop in noninfectious by: Abstract. The systemic inflammatory response is elicited in a multitude of clinical scenarios including infection, tissue injury (surgical or traumatic), ischemia-reperfusion, post-cardiopulmonary bypass, as well as autoimmune by: 2. Get this from a library! Cytokines in Severe Sepsis and Septic Shock. [Heinz Redl; Günther Schlag] -- This book deals with the central role of cytokines in the generalized inflammatory response of the host as the consequence of severe infection/endotoxin action. International specialists cover.